Redox-regulated processes are relevant to wound healing. A balance between bioavailable nitric oxide (NO) concentration and a level of oxidative and nitroxidative stress in wounds may be crucial in wound repair. The highly beneficial effect of bioavailable NO is attributed to scavenging of superoxide, which is the main component of oxidative stress. Also, the high level of NO can influence angiogenesis and endothelial/skeletal muscle cell remodeling and proliferation. However, under conditions of excessive and prolonged production of oxygen in wounds, the supplementation of NO can be evolved in significant increase in nitroxidative stress. Here we briefly review the role of NO, and focus on oxygen and peroxynitrous acid (major components of oxidative and nitroxidative stress respectively) in the normal and impaired process of wound healing.

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